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R&D expenditure, Millions of euro (Millions of euro)
| 2000 | 2005 | 2011 | 2012 |
| Groningen | | 386.00 | 486.47 | 490.42 |
| Friesland | 94.00 | 115.00 | 147.69 | 155.85 |
| Drenthe | | 82.00 | 106.09 | 99.62 |
| Overijssel | 375.00 | 375.00 | 747.63 | 608.45 |
| Gelderland | 768.00 | 1,220.00 | 1,464.41 | 1,516.17 |
| Flevoland | 165.00 | 139.00 | 173.14 | 202.02 |
| Utrecht | 616.00 | 928.00 | 1,139.60 | 1,148.04 |
| Noord-Holland | 1,440.00 | 1,505.00 | 2,234.62 | 2,390.45 |
| Zuid-Holland | 1,514.00 | 1,925.00 | 2,647.28 | 2,658.88 |
| Zeeland | | 58.00 | 45.30 | 61.44 |
| Noord-Brabant | 1,824.00 | 2,353.00 | 2,322.16 | 2,498.98 |
| Limburg | 519.00 | 687.00 | 720.93 | 682.30 |